3H07-10 2021/03/20 13:30 °ìÈÌ¹Ö±é ¥ß¡¼¥Æ¥£¥ó¥°¥ë¡¼¥à H ¥Õ¥é¥Ü¥Î¥¤¥É²½¹çʪ¤Ë¤è¤ëº«Ã¥Æ¥í¥¤¥É¥Û¥ë¥â¥óÀ¸¹çÀ®¹ÚÁÇNoppera-bo¤ÎÁ˳²¡§¹½Â¤À¸Êª³ØŪ²òÀϤÈÀ¸Êª³èÀ¸¡Äê Inhibition of insect steroid hormone biosynthetic enzyme Noppera-bo by flavonoid compounds: Structural biological analysis and biological activity assay ¡û³¤Ï·¸¶ ²ÂÆà1°ðÍÕ Ï·Ã1¾®½Ë ¹§ÂÀϺ2üâë ÂçÊå3ÅÏîµ ÀéÄá3º£Â¼ ÍýÀ¤4²¬Éô δµÁ4¾®Åç ¹¨·ú4º´µ×´Ö Ãκ´»Ò5²Å¹Ç ÍÎΦ5Æ£Àî ͺÂÀ6°æ¾å ±Ñ»Ë6ËÜ´Ö ¸÷µ®3ÀéÅÄ ½ÓºÈ2𱩠δ²ð1,7¡ûKana EBIHARA1 Kazue INABA1 Kotaro KOIWAI2 Daisuke TAKAYA3 Chiduru WATANABE3 Riyo IMAMURA4 Takayoshi OKABE4 Hirotatsu KOJIMA4 Chisako SAKUMA5 Hirotaka KANUKA5 Yuuta FUJIKAWA6 Hideshi INOUE6 Teruki HONMA3 Toshiya SENDA2 Ryusuke NIWA1,7 1ÃÞÇÈÂ硦À¸Ì¿´Ä¶¡¢2¹â¥¨¥Í¸¦¡¦Êª¹½¸¦¡¦¹½Â¤À¸Êª¡¢3Íý¸¦(BDR) À©¸æʬ»ÒÀ߷ס¢4ÅìÂ硦ÁÏÌôµ¡¹½¡¢5»ü·Ã°åÂ硦ǮÂÓ°å³Ø¡¢6ÅìµþÌôÂ硦À¸Ì¿²Ê³Ø¡¢7ÃÞÇÈÂ硦TARA ¥» 1Graduate School of Life and Environmental Sciences, University of Tsukuba, 2Structural biology research center, Institute of Materials Structure Science, High Energy Accelerator Research Organization KEK, 3Systems and Structural Biology Center, RIKEN(BDR), 4Drug Discovery Initiative, University of Tokyo, 5Department of Tropical Medicine, Center for Medical Entomology, The Jikei University School of Medicine, 6School of Life Sciences, Tokyo University of Pharmacy and Life sciences, 7Life Science Center of Tsukuba Advanced Research Alliance, University of Tsukuba X-ray crystal structure analysis / Drug discovery / Mosquito Í×»ÝËÜʸ¤Ï¥È¥Ã¥×¥Ú¡¼¥¸¤«¤é¥í¥°¥¤¥ó¤ò¤·¤Æĺ¤¯¤Èɽ¼¨¤µ¤ì¤Þ¤¹¡£