¥¡¼¥ï¡¼¥É:Alzheimer's disease ¤Î¸¡º÷·ë²Ì / 1 1 - 7 / 7 <<< 1 >>> / 1 1 - 7 / 7 <<< 1 >>> 3E05-07 2022/03/17 11:00 ¥ß¡¼¥Æ¥£¥ó¥°¥ë¡¼¥à E ¥¢¥ß¥í¥¤¥É¦Â¤Î¿À·ÐÆÇÀ¤òÍÞÀ©¤¹¤ë¿·µ¬¥Ú¥×¥Á¥É¤Î³«È¯ Rationally Designed Peptide Modulators of Amyloid ¦Â Toxicity in Alzheimer¡Çs Disease ¡ûÊ¡¸¶ ·é1¡¢¿¹ °ì·û1¡¢²»³ ²ÂÀ¸2¡¢»°ß· δ»Ë2¡¢¿åÌî ÈþÎï1¡¢½Ð¿å ÍDzð2¡¢¼Æ¾Â ¼Á»Ò1¡¢ÂçÌî ¾´»Ò2 ¡ûKiyoshi FUKUHARA1, Kazunori MORI1, Yoshio OKIYAMA2, Takashi MISAWA2, Mirei MIZUNO1, Yosuke DEMIZU2, Motoko SHIBANUMA1, Akiko OHNO2 1¾¼ÏÂÂçÌô¡¢2¹ñ±Ò¸¦ 1Showa Univ., 2NIHS 3F02-06 2022/03/17 09:30 ¥ß¡¼¥Æ¥£¥ó¥°¥ë¡¼¥à F 3²óÂоΤʤé¤Ó¤ËÊ¿¹Ô·¿A¦Â40¤Î3ÎÌÂÎ¥â¥Ç¥ë¤Î¹çÀ®¤Èµ¡Ç½²òÀÏ Synthesis and characterization of trimer models of A¦Â40 with C3-symmetric or parallel structure ¡ûÆâÌî ÊâÈþ1¡¢Æþ¹¾ ͳÈþ1¡¢ÄÍÌî Àé¿Ò1¡¢ÀîÀ¥ ÂÙ¼£2¡¢×¢À¥ ¸¼£2¡¢Æþ¹¾ °ì¹À1 ¡ûAyumi UCHINO1, Yumi IRIE1, Chihiro TSUKANO1, Taiji KAWASE2, Kenji HIROSE2, Kazuhiro IRIE1 1µþÂ籡ÇÀ¡¢2ÆüËÜ¥¦¥©¡¼¥¿¡¼¥º 1Kyoto Univ., 2Nihon Waters K. K. 3F02-07 2022/03/17 09:30 ¥ß¡¼¥Æ¥£¥ó¥°¥ë¡¼¥à F ¥¢¥ß¥í¥¤¥É¦Â-40¤ÎÆÇÀ£²ÎÌÂÎ¥â¥Ç¥ë¤Ë¤ª¤±¤ë¥ê¥ó¥«¡¼Ä¹¤Î¶Å½¸Ç½¤ÈºÙ˦ÆÇÀ¤ËµÚ¤Ü¤¹±Æ¶Á Effects of the length of the linker on the aggregative ability and cytotoxicity in the toxic dimer model of A¦Â40 ¡ûÃÞ¸å ʸ³¾1¡¢Æþ¹¾ ͳÈþ1¡¢ÆâÌî ÊâÈþ1¡¢ÄÍÌî Àé¿Ò1¡¢ÀîÀ¥ ÂÙ»Ê2¡¢×¢À¥ ¸¼£2¡¢Æþ¹¾ °ì¹À1 ¡ûAYAKA CHIKUGO1, YUMI IRIE1, AYUMI UCHINO1, CHIHIRO TSUKANO1, TAIJI KAWASE2, KENJI HIROSE2, KAZUHIRO IRIE1 1µþÂçÇÀ¡¢2ÆüËÜ¥¦¥©¡¼¥¿¡¼¥º 1Kyoto Univ., 2Nihon Waters 3H07-11 2022/03/17 13:30 ¥ß¡¼¥Æ¥£¥ó¥°¥ë¡¼¥à H ¥Û¥¨¥¤Í³Íè¥Ú¥×¥Á¥É¦Â¥é¥¯¥È¥ê¥ó¤Ï¥Þ¥¦¥¹¤ª¤è¤Ó¥Ò¥ÈiPSºÙ˦ͳÍ襢¥ë¥Ä¥Ï¥¤¥Þ¡¼ÉÂ¥â¥Ç¥ë¿À·ÐºÙ˦¤Î¥ß¥È¥³¥ó¥É¥ê¥¢µ¡Ç½°Û¾ï¤ò²þÁ±¤¹¤ë ¦Â-Lactolin rescues mitochondrial dysfunction in A¦Â-treated mouse hippocampal neuronal cells and a human iPSC-derived neuronal cell model of Alzheimer¡Çs disease ¡û°½Éô 㹨¡¢üⶶ Àé²Â¡¢Âç²° ÎçÆà¡¢°¤Ìî ÂÙµ× ¡ûTatsuhiro AYABE, Chika TAKAHASHI, Rena OHYA, Yasuhisa ANO ¥¥ê¥óHD¡¦Ãæ±û¸¦ Kirin Holdings Co., Ltd 4F07-06 2022/03/18 13:30 ¥ß¡¼¥Æ¥£¥ó¥°¥ë¡¼¥à F Synthesis and evaluation of catechol derivatives as an amyloid-beta aggregation inhibitor ¡ûFusheng XU, Keima Osawa, Misato Tajiri, Ryusei Endo, Koki Makabe, Hiroyuki Konno Yamagata Univ. 4G08-01 2022/03/18 14:00 ¥ß¡¼¥Æ¥£¥ó¥°¥ë¡¼¥à G ¥¢¥ë¥Ä¥Ï¥¤¥Þ¡¼É´µ¼ÔÂÐ¾Ý¥í¥¹¥Þ¥ê¥ó»À²ðÆþ»î¸³¤Ë¤ª¤±¤ëmicroRNAȯ¸½ÊÑÆ°¤ª¤è¤Óµ¡Ç½²òÀÏ MiRNA profiles and their functional characteristics of patients with Alzheimer¡Çs disease after rosmarinic acid intake ¡û»³ËÜ Ë¨Çµ1¡¢¼Ä¸¶ ¤â¤¨»Ò2¡¢É͸ý µ£2¡¢¾®Ìî ¸ÆóϺ2¡¢»³ÅÄ Àµ¿Î2¡¢»°ºä ¹ª1¡¢°¤Éô ·¼»Ò1¡¢¾®ÎÓ ¾´»Ò1 ¡ûMoeno YAMAMOTO1, Moeko SHINOHARA2, Tsuyoshi HAMAGUCHI2, Kenjiro ONO2, Masahito YAMADA2, Takumi MISAKA1, Keiko ABE1, Shoko KOBAYASHI1 1ÅìÂçÇÀ¡¢2¶âÂô°å 1The Univ. of Tokyo, 2Kanazawa Univ. 4I03-02 2022/03/18 10:00 ¥ß¡¼¥Æ¥£¥ó¥°¥ë¡¼¥à I 2·¿ÅüǢɤ¬Ç¾¥¤¥ó¥¹¥ê¥ó¥·¥°¥Ê¥ë¤È¥¢¥ë¥Ä¥Ï¥¤¥Þ¡¼ÉÂÂÖ¤ËÍ¿¤¨¤ë±Æ¶Á Effects of type 2 diabetes on brain insulin signaling and Alzheimer's disease ÄÔ ÎµÊ¿1¡¢ÅÄǷƬ ÂçÊå1¡¢²¦ ±¶1¡¢´Ý»³ ¤á¤°¤ß1¡¢¹õ´ä ÃÒ·ÃÈþ1¡¢ÀÆÆ£ µ®»Ö2¡¢À¾Æ» δ¿Ã2¡¢¡ûÅĸý ÌÀ»Ò1 Ryuhei TSUJI1, Daisuke TANOKASHIRA1, Wei WANG1, Megumi MARUYAMA1, Chiemi KUROIWA1, Takashi SAITO2, Takaomi SAIDO2, ¡ûAkiko TAGUCHI1 1¹ñΩĹ¼÷°åΟ¦µæ¥»¥ó¥¿¡¼¡¢2Íý²½³Ø¸¦µæ½ê 1National Center for Geriatrics and Gerontology, 2RIKEN / 1 1 - 7 / 7 <<< 1 >>> / 1 1 - 7 / 7 <<< 1 >>>