3E01-07 2023/03/16 09:00 °ìÈÌ¹Ö±é ¥ß¡¼¥Æ¥£¥ó¥°¥ë¡¼¥à E ¥Í¥Ã¥¿¥¤¥·¥Þ¥«Í³Íè¤Î¥°¥ë¥¿¥Á¥ª¥óS-¥È¥é¥ó¥¹¥Õ¥§¥é¡¼¥¼¤ËÂФ¹¤ë¿·µ¬»¦Ãî²½¹çʪ¤ÎºîÍѵ¡½ø Mode of action of new compounds against glutathione S-transferase Noppera-bo from Aedes aegypti ¡û³¤Ï·¸¶ ²ÂÆà1°ðÍÕ Ï·Ã2ÀéÅÄ Èþµª3°Â¹»Ò ¥æ¥ß4º´µ×´Ö Ãκ´»Ò5¾®½Ë ¹§ÂÀϺ3üâë ÂçÊå6ÅÏîµ ÀéÄá6º£Â¼ ÍýÀ¤7²¬Éô δµÁ7¾®Åç ¹¨·ú7²Å¹Ç ÍÎΦ5Æ£Àî ͺÂÀ8°æ¾å ±Ñ»Ë8ËÜ´Ö ¸÷µ®6ÀéÅÄ ½ÓºÈ3𱩠δ²ð9¡ûKana EBIHARA1 Kazue INABA2 Miki SENDA3 Yumi ABIKO4 Chisako SAKUMA5 Kotaro KOIWAI3 Daisuke TAKAYA6 Chiduru WATANABE6 Riyo IMAMURA7 Takayoshi OKABE7 Hirotatsu KOJIMA7 Hirotaka KANUKA5 Yuuta FUJIKAWA8 Hideshi INOUE8 Teruki HONMA6 Toshiya SENDA3 Ryusuke NIWA9 1ÃÞÇÈÂç³ØÂç³Ø±¡¡¦Íý¹©¾ðÊóÀ¸Ì¿¡¢2ÃÞÇÈÂç³ØÂç³Ø±¡¡¦À¸Ì¿´Ä¶¡¢3¹â¥¨¥Í¥ë¥®¡¼²Ã®´ï¸¦µæµ¡¹½¡¦Êª¹½¸¦¡¢4ÃÞÇÈÂç³Ø¡¦°å³Ø°åÎÅ·Ï¡¢5Åìµþ»ü·Ã²ñ°å²ÊÂç³Ø¡¢6Íý²½³Ø¸¦µæ½ê¡¦À¸Ì¿µ¡Ç½²Ê³Ø¸¦µæ¥»¥ó¥¿¡¼¡¢7ÅìµþÂç³Ø¡¦ÁÏÌôµ¡¹½¡¢8ÅìµþÌô²ÊÂç³Ø¡¦À¸Ì¿²Ê³ØÉô¡¢9ÃÞÇÈÂç³Ø¡¦À¸Â¸¥À¥¤¥Ê¥ß¥¯¥¹¸¦µæ¥»¥ó¥¿¡¼ 1Graduate School of Science and Technology, University of Tsukuba, 2Graduate School of Life and Environmental Sciences, University of Tsukuba, 3Structural biology research center, Institute of Materials Structure Science, High Energy Accelerator Research Organization KEK, 4Grad. Sch. of Comprehensive Human Sciences Majors of Medical Sciences, University of Tsukuba, 5The Jikei University School of Medicine, 6Center for Biosystems Dynamics Research, RIKEN, 7Drug Discovery Initiative, University of Tokyo, 8Tokyo University of Pharmacy and Life sciences, 9Life Science Center of Tsukuba Advanced Research Alliance, University of Tsukuba gultathione S-transferase / mosquito / X-ray crystallography ¢¨ Í×¥í¥°¥¤¥ó Í×»ÝËÜʸ¤Ï¥È¥Ã¥×¥Ú¡¼¥¸¤«¤é¥í¥°¥¤¥ó¤ò¤·¤Æĺ¤¯¤Èɽ¼¨¤µ¤ì¤Þ¤¹¡£